                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc.
       Hariharan, Kandasamy
       Dong, Jianying

<120>  THERAPEUTIC COMBINATIONS OF ANTI-IGF-1R ANTIBODIES AND OTHER COMPOUNDS

<130>  2159.100PC07

<140>  TBA
<141>  2009-04-10

<150>  61/071,087
<151>  2008-04-11

<160>  157   

<170>  PatentIn version 3.3

<210>  1
<211>  4989
<212>  DNA
<213>  Homo sapiens

<400>  1
tttttttttt ttttgagaaa gggaatttca tcccaaataa aaggaatgaa gtctggctcc     60

ggaggagggt ccccgacctc gctgtggggg ctcctgtttc tctccgccgc gctctcgctc    120

tggccgacga gtggagaaat ctgcgggcca ggcatcgaca tccgcaacga ctatcagcag    180

ctgaagcgcc tggagaactg cacggtgatc gagggctacc tccacatcct gctcatctcc    240

aaggccgagg actaccgcag ctaccgcttc cccaagctca cggtcattac cgagtacttg    300

ctgctgttcc gagtggctgg cctcgagagc ctcggagacc tcttccccaa cctcacggtc    360

atccgcggct ggaaactctt ctacaactac gccctggtca tcttcgagat gaccaatctc    420

aaggatattg ggctttacaa cctgaggaac attactcggg gggccatcag gattgagaaa    480

aatgctgacc tctgttacct ctccactgtg gactggtccc tgatcctgga tgcggtgtcc    540

aataactaca ttgtggggaa taagccccca aaggaatgtg gggacctgtg tccagggacc    600

atggaggaga agccgatgtg tgagaagacc accatcaaca atgagtacaa ctaccgctgc    660

tggaccacaa accgctgcca gaaaatgtgc ccaagcacgt gtgggaagcg ggcgtgcacc    720

gagaacaatg agtgctgcca ccccgagtgc ctgggcagct gcagcgcgcc tgacaacgac    780

acggcctgtg tagcttgccg ccactactac tatgccggtg tctgtgtgcc tgcctgcccg    840

cccaacacct acaggtttga gggctggcgc tgtgtggacc gtgacttctg cgccaacatc    900

ctcagcgccg agagcagcga ctccgagggg tttgtgatcc acgacggcga gtgcatgcag    960

gagtgcccct cgggcttcat ccgcaacggc agccagagca tgtactgcat cccttgtgaa   1020

ggtccttgcc cgaaggtctg tgaggaagaa aagaaaacaa agaccattga ttctgttact   1080

tctgctcaga tgctccaagg atgcaccatc ttcaagggca atttgctcat taacatccga   1140

cgggggaata acattgcttc agagctggag aacttcatgg ggctcatcga ggtggtgacg   1200

ggctacgtga agatccgcca ttctcatgcc ttggtctcct tgtccttcct aaaaaacctt   1260

cgcctcatcc taggagagga gcagctagaa gggaattact ccttctacgt cctcgacaac   1320

cagaacttgc agcaactgtg ggactgggac caccgcaacc tgaccatcaa agcagggaaa   1380

atgtactttg ctttcaatcc caaattatgt gtttccgaaa tttaccgcat ggaggaagtg   1440

acggggacta aagggcgcca aagcaaaggg gacataaaca ccaggaacaa cggggagaga   1500

gcctcctgtg aaagtgacgt cctgcatttc acctccacca ccacgtcgaa gaatcgcatc   1560

atcataacct ggcaccggta ccggccccct gactacaggg atctcatcag cttcaccgtt   1620

tactacaagg aagcaccctt taagaatgtc acagagtatg atgggcagga tgcctgcggc   1680

tccaacagct ggaacatggt ggacgtggac ctcccgccca acaaggacgt ggagcccggc   1740

atcttactac atgggctgaa gccctggact cagtacgccg tttacgtcaa ggctgtgacc   1800

ctcaccatgg tggagaacga ccatatccgt ggggccaaga gtgagatctt gtacattcgc   1860

accaatgctt cagttccttc cattcccttg gacgttcttt cagcatcgaa ctcctcttct   1920

cagttaatcg tgaagtggaa ccctccctct ctgcccaacg gcaacctgag ttactacatt   1980

gtgcgctggc agcggcagcc tcaggacggc tacctttacc ggcacaatta ctgctccaaa   2040

gacaaaatcc ccatcaggaa gtatgccgac ggcaccatcg acattgagga ggtcacagag   2100

aaccccaaga ctgaggtgtg tggtggggag aaagggcctt gctgcgcctg ccccaaaact   2160

gaagccgaga agcaggccga gaaggaggag gctgaatacc gcaaagtctt tgagaatttc   2220

ctgcacaact ccatcttcgt gcccagacct gaaaggaagc ggagagatgt catgcaagtg   2280

gccaacacca ccatgtccag ccgaagcagg aacaccacgg ccgcagacac ctacaacatc   2340

accgacccgg aagagctgga gacagagtac cctttctttg agagcagagt ggataacaag   2400

gagagaactg tcatttctaa ccttcggcct ttcacattgt accgcatcga tatccacagc   2460

tgcaaccacg aggctgagaa gctgggctgc agcgcctcca acttcgtctt tgcaaggact   2520

atgcccgcag aaggagcaga tgacattcct gggccagtga cctgggagcc aaggcctgaa   2580

aactccatct ttttaaagtg gccggaacct gagaatccca atggattgat tctaatgtat   2640

gaaataaaat acggatcaca agttgaggat cagcgagaat gtgtgtccag acaggaatac   2700

aggaagtatg gaggggccaa gctaaaccgg ctaaacccgg ggaactacac agcccggatt   2760

caggccacat ctctctctgg gaatgggtcg tggacagatc ctgtgttctt ctatgtccag   2820

gccaaaacag gatatgaaaa cttcatccat ctgatcatcg ctctgcccgt cgctgtcctg   2880

ttgatcgtgg gagggttggt gattatgctg tacgtcttcc atagaaagag aaataacagc   2940

aggctgggga atggagtgct gtatgcctct gtgaacccgg agtacttcag cgctgctgat   3000

gtgtacgttc ctgatgagtg ggaggtggct cgggagaaga tcaccatgag ccgggaactt   3060

gggcaggggt cgtttgggat ggtctatgaa ggagttgcca agggtgtggt gaaagatgaa   3120

cctgaaacca gagtggccat taaaacagtg aacgaggccg caagcatgcg tgagaggatt   3180

gagtttctca acgaagcttc tgtgatgaag gagttcaatt gtcaccatgt ggtgcgattg   3240

ctgggtgtgg tgtcccaagg ccagccaaca ctggtcatca tggaactgat gacacggggc   3300

gatctcaaaa gttatctccg gtctctgagg ccagaaatgg agaataatcc agtcctagca   3360

cctccaagcc tgagcaagat gattcagatg gccggagaga ttgcagacgg catggcatac   3420

ctcaacgcca ataagttcgt ccacagagac cttgctgccc ggaattgcat ggtagccgaa   3480

gatttcacag tcaaaatcgg agattttggt atgacgcgag atatctatga gacagactat   3540

taccggaaag gaggcaaagg gctgctgccc gtgcgctgga tgtctcctga gtccctcaag   3600

gatggagtct tcaccactta ctcggacgtc tggtccttcg gggtcgtcct ctgggagatc   3660

gccacactgg ccgagcagcc ctaccagggc ttgtccaacg agcaagtcct tcgcttcgtc   3720

atggagggcg gccttctgga caagccagac aactgtcctg acatgctgtt tgaactgatg   3780

cgcatgtgct ggcagtataa ccccaagatg aggccttcct tcctggagat catcagcagc   3840

atcaaagagg agatggagcc tggcttccgg gaggtctcct tctactacag cgaggagaac   3900

aagctgcccg agccggagga gctggacctg gagccagaga acatggagag cgtccccctg   3960

gacccctcgg cctcctcgtc ctccctgcca ctgcccgaca gacactcagg acacaaggcc   4020

gagaacggcc ccggccctgg ggtgctggtc ctccgcgcca gcttcgacga gagacagcct   4080

tacgcccaca tgaacggggg ccgcaagaac gagcgggcct tgccgctgcc ccagtcttcg   4140

acctgctgat ccttggatcc tgaatctgtg caaacagtaa cgtgtgcgca cgcgcagcgg   4200

ggtggggggg gagagagagt tttaacaatc cattcacaag cctcctgtac ctcagtggat   4260

cttcagttct gcccttgctg cccgcgggag acagcttctc tgcagtaaaa cacatttggg   4320

atgttccttt tttcaatatg caagcagctt tttattccct gcccaaaccc ttaactgaca   4380

tgggccttta agaaccttaa tgacaacact taatagcaac agagcacttg agaaccagtc   4440

tcctcactct gtccctgtcc ttccctgttc tccctttctc tctcctctct gcttcataac   4500

ggaaaaataa ttgccacaag tccagctggg aagccctttt tatcagtttg aggaagtggc   4560

tgtccctgtg gccccatcca accactgtac acacccgcct gacaccgtgg gtcattacaa   4620

aaaaacacgt ggagatggaa atttttacct ttatctttca cctttctagg gacatgaaat   4680

ttacaaaggg ccatcgttca tccaaggctg ttaccatttt aacgctgcct aattttgcca   4740

aaatcctgaa ctttctccct catcggcccg gcgctgattc ctcgtgtccg gaggcatggg   4800

tgagcatggc agctggttgc tccatttgag agacacgctg gcgacacact ccgtccatcc   4860

gactgcccct gctgtgctgc tcaaggccac aggcacacag gtctcattgc ttctgactag   4920

attattattt gggggaactg gacacaatag gtctttctct cagtgaaggt ggggagaagc   4980

tgaaccggc                                                           4989


<210>  2
<211>  1367
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  3
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  3
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct ccttactcta tgctttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcggttctt ctggtggctc tactcgttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac accgccatgt attactgtgc acgggtacgg    300

gggatccttc attacgatat tttgattggt agaaatctct actactacta catggacgtc    360

tggggcaaag ggaccacggt caccgtctca agc                                 393


<210>  4
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ser Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Gly Ile Leu His Tyr Asp Ile Leu Ile Gly Arg Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  5

Pro Tyr Ser Met Leu 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  6

Ser Ile Gly Ser Ser Gly Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  7

Val Arg Gly Ile Leu His Tyr Asp Ile Leu Ile Gly Arg Asn Leu Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Met Asp Val 
            20          


<210>  8
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  8
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aagtacacta tgcattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcgtttctt ctggtggctg gactgattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatcgg    300

agtatagcag cagctggtac cggttggtct gtgagttttg tggactggtt cgacccctgg    360

ggccagggaa ccctggtcac cgtctcaagc                                     390


<210>  9
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Val Ser Ser Gly Gly Trp Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Ile Ala Ala Ala Gly Thr Gly Trp Ser Val Ser 
            100                 105                 110         


Phe Val Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  10

Lys Tyr Thr Met His 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  11

Ser Ile Val Ser Ser Gly Gly Trp Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  12

Asp Arg Ser Ile Ala Ala Ala Gly Thr Gly Trp Ser Val Ser Phe Val 
1               5                   10                  15      


Asp Trp Phe Asp Pro 
            20      


<210>  13
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  13
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct atttaccgta tgcagtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctggt atctctcctt ctggtggcac tacttggtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagatggagc    300

gggggttcgg gctatgcttt tgatatctgg ggccaaggga caatggtcac cgtctcaagc    360


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Arg Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Pro Ser Gly Gly Thr Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Gly Gly Ser Gly Tyr Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120

<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  15

Ile Tyr Arg Met Gln 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  16

Gly Ile Ser Pro Ser Gly Gly Thr Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  17

Trp Ser Gly Gly Ser Gly Tyr Ala Phe Asp Ile 
1               5                   10      


<210>  18
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  18
gaggtccagc tgttggagtc cggcggtggc ctggtgcagc ctggggggtc cctgagactc     60

tcctgcgcag ctagcggctt caccttcagc atttaccgta tgcagtgggt gcgccaggct    120

cctggaaagg ggctggagtg ggtttccggt atctctccct ctggtggcac gacgtggtat    180

gctgactccg tgaagggccg gttcacaatc tccagagaca attccaagaa cactctgtac    240

ctgcaaatga acagcctgag agctgaggat actgcagtgt actactgcgc cagatggtcc    300

gggggctccg gatacgcctt cgacatctgg ggacagggaa ccatggtcac cgtctcaagc    360


<210>  19
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  19
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aattaccata tggcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atctctccta ctggtggccg tactacttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccacat attactgtgc gagagcgggg    300

tacagctatg gttatggcta ctttgactac tggggccagg gaaccctggt caccgtctca    360

agc                                                                  363


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


His Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Thr Gly Gly Arg Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Tyr Ser Tyr Gly Tyr Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  21

Asn Tyr His Met Ala 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  22

Val Ile Ser Pro Thr Gly Gly Arg Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  23

Ala Gly Tyr Ser Tyr Gly Tyr Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  24
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  24
gaggtccagc tgttggagtc cggcggtggc ctggtgcagc ctggggggtc cctgagactc     60

tcctgcgcag ctagcggctt caccttcagc aattaccaca tggcctgggt gcgccaggct    120

cctggaaagg ggctggagtg ggtttccgtg atctctccta ccggtggcag gaccacttac    180

gctgactccg tgaagggccg gttcacaatc tccagagaca attccaagaa cactctgtac    240

ctgcaaatga acagcctgag agctgaggat actgcaacat actactgcgc cagagccggg    300

tactcctacg gctacggata cttcgactac tggggacagg gaaccctggt caccgtctca    360

agc                                                                  363


<210>  25
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  25
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aagtacatga tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttat atctctcctt ctggtggcct tacttggtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatgga    300

gctagaggct acggtatgga cgtctggggc caagggacca cggtcaccgt ctcaagc       357


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Arg Gly Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  27

Lys Tyr Met Met Ser 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  28

Tyr Ile Ser Pro Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  29

Asp Gly Ala Arg Gly Tyr Gly Met Asp Val 
1               5                   10  


<210>  30
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  30
gaggtccagc tgttggagtc cggcggtggc ctggtgcagc ctggggggtc cctgagactc     60

tcctgcgcag ctagcggctt caccttcagc aagtacatga tgtcttgggt gcgccaggct    120

cctggaaagg ggctggagtg ggtttcctat atctctccct ctggtggcct gacgtggtat    180

gctgactccg tgaagggccg gttcacaatc tccagagaca attccaagaa cactctgtac    240

ctgcaaatga acagcctgag agctgaggat actgcagtgt actactgcgc cagagatggg    300

gctagaggat acggaatgga cgtctgggga cagggaacca ccgtcaccgt ctcaagc       357


<210>  31
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  31
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aattacccta tgtattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctcttctt ctggtggccg tactgtttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatcga    300

tggtccagat ctgcagctga atatgggttg ggtggctact ggggccaggg aaccctggtc    360

accgtctcaa gc                                                        372


<210>  32
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Pro Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser Ser Gly Gly Arg Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Trp Ser Arg Ser Ala Ala Glu Tyr Gly Leu Gly Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  33

Asn Tyr Pro Met Tyr 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  34

Arg Ile Ser Ser Ser Gly Gly Arg Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  35

Asp Arg Trp Ser Arg Ser Ala Ala Glu Tyr Gly Leu Gly Gly Tyr 
1               5                   10                  15  


<210>  36
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  36
gaggtccagc tgttggagtc cggcggtggc ctggtgcagc ctggggggtc cctgagactc     60

tcctgcgcag ctagcggctt caccttcagc aattacccca tgtactgggt gcgccaggct    120

cctggaaagg ggctggagtg ggtttccagg atctctagca gcggtggcag gaccgtgtac    180

gctgactccg tgaagggccg gttcacaatc tccagagaca attccaagaa cactctgtac    240

ctgcaaatga acagcctgag agctgaggat actgcagtgt actactgcgc cagagatagg    300

tggtccagat ctgcagccga gtacggactg gggggctact ggggacaggg aaccctggtc    360

accgtctcaa gc                                                        372


<210>  37
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  37
caggttcagc tgcagcagtc tggacctgag ctagtgaagc ctggggcttc agtgaagatg     60

tcctgcaagg cttctggaaa cacattcact gactatgtta taaactgggt gaagcagaga    120

actggacagg gccttgagtg gattggagag atttatcctg gaaatgaaaa tacttattac    180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccaa cacagcctac    240

atgcagctca gtagcctgac atctgaggac tctgcggtct atttctgtgc aagagggatt    300

tattactacg gtagtaggac gaggactatg gactactggg gtcaaggaac ctcagtcacc    360

gtctcctca                                                            369


<210>  38
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  38

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Asn Glu Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Tyr Tyr Tyr Gly Ser Arg Thr Arg Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  39

Asp Tyr Val Ile Asn 
1               5   


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  40

Ile Tyr Pro Gly Asn Glu Asn Thr Tyr Tyr Asn Glu Lys Phe Lys Gly 
1               5                   10                  15      


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  41

Gly Ile Tyr Tyr Tyr Gly Ser Arg Thr Arg Thr Met Asp Tyr 
1               5                   10                  


<210>  42
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  42
gacgtccaac tgcaggagtc tggacctgac ctggtgaaac cttctcagtc actttcactc     60

acctgcactg tcactggcta ctccatcacc agtggttata gctggcactg gatccggcag    120

tttccaggaa acaaactgga atggatgggc tacatacact acagtggtgg cactaactac    180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc    240

ctccagttga attctgtgac tactgaggac acagccacat attactgtgc aagatcgggg    300

tacggctaca ggagtgcgta ctattttgac tactggggcc aagggaccac ggtcaccgtc    360

tcctca                                                               366


<210>  43
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  43

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Gly Tyr Arg Ser Ala Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  44

Ser Gly Tyr Ser Trp His 
1               5       


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  45

Tyr Ile His Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  46

Ser Gly Tyr Gly Tyr Arg Ser Ala Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  47
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  47
caaatacagt tggttcagag cggacctgag ctgaagaagc ctggagagac agtcaagatc     60

tcctgcaagg cttctgggta taccttcaca aaccatggaa tgaactgggt gaagcaggct    120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct ccactggaga gccaacatat    180

gctgatgact tcaagggacg ttttgccttc tctttggaaa cctctgccag cactgccttt    240

ttgcagatca acaacctcaa aaatgaggac acggcttcat atttctgtgc aagtcccctc    300

tactatatgt acgggcggta tatcgatgtc tggggcgcag ggaccgcggt caccgtctcc    360

tca                                                                  363


<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  48

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Asn Thr Ser Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ser Tyr Phe Cys Ala 
                85                  90                  95      


Ser Pro Leu Tyr Tyr Met Tyr Gly Arg Tyr Ile Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Ala Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  49

Asn His Gly Met Asn 
1               5   


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  50

Asn Thr Ser Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly 
1               5                   10                  15  


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  51

Pro Leu Tyr Tyr Met Tyr Gly Arg Tyr Ile Asp Val 
1               5                   10          


<210>  52
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  52
acgtccaact gcaggagtct ggacctgacc tggtgaaacc ttctcagtca ctttcactca     60

cctgcactgt cactggctac tccatcacca gtggttatag ctggcactgg atccggcagt    120

ttccaggaaa caaactggaa tggatgggct acatacacta cagtggtggc actaactaca    180

acccatctct caaaagtcga atctctatca ctcgagacac atccaagaac cagttcttcc    240

tccagttgaa ttctgtgact actgaggaca cagccacata ttactgtgca agatcggggt    300

acggctacag gagtg                                                     315


<210>  53
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  53

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Gly Tyr Arg Ser Ala Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  54

Ser Gly Tyr Ser Trp His 
1               5       


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  55

Tyr Ile His Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  56

Ser Gly Tyr Gly Tyr Arg Ser Ala Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  57
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  57
cagatccagt tggtgcagtc tggacctgac ctgaagaagc ctggagagac agtcaagatc     60

tcctgcaagg cttctgggta taccttcaca aaccatggaa tgaactgggt gaagcaggct    120

ccaggaaagg atttaaagtg gatgggctgg ataaacacca acactggaga gccaacatat    180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat    240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagtcccctc    300

tactatagga acgggcgata cttcgatgtc tggggcgcag ggaccacggt caccgtctcc    360


<210>  58
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  58

Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Asp Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Pro Leu Tyr Tyr Arg Asn Gly Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  59

Asn His Gly Met Asn 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  60

Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  61

Pro Leu Tyr Tyr Arg Asn Gly Arg Tyr Phe Asp Val 
1               5                   10          


<210>  62
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  62
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg     60

tcctgtaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg    120

cctggacaag gccttgagtg gattggagag attaatccta cctacggtcg tagtaattac    180

aatgagaagt tcaagagtaa ggccacactg actgtagaca aatcctccag cacagcctac    240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagattagta    300

cgcctacggt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc ctca          354


<210>  63
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  63

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Tyr Gly Arg Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  64

Ser Tyr Trp Met His 
1               5   


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  65

Glu Ile Asn Pro Thr Tyr Gly Arg Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable heavy chain sequence

<400>  66

Leu Val Arg Leu Arg Tyr Phe Asp Val 
1               5                   


<210>  67
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  67
cagtacgaat tgactcagcc gccctcggtg tctgaggccc cccggcagag ggtcaccatc     60

tcctgttctg gaagcagctc caacatcgga aataatgcta taaactggta ccagcaactc    120

ccaggaaagc ctcccaaact cctcatctat tatgatgatc tgttgccctc aggggtctct    180

gaccgattct ctggctccaa gtctggcacc tcaggctccc tggccatcag tgggctgcag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acaacctgaa tggtgtgatt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  68
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  68

Gln Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Ile Asn Trp Tyr Gln Gln Leu Pro Gly Lys Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Asn Leu 
                85                  90                  95      


Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  69

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Ile Asn 
1               5                   10              


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  70

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  71

Ala Ala Trp Asp Asp Asn Leu Asn Gly Val Ile 
1               5                   10      


<210>  72
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  72
gacatccaga tgacccagtc tccactctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattaac ggctacttaa attggtatca gcagaaacca    120

gggaaagccc ctaacctcct gatctacgct acatccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta cccccccgta cacttttggc    300

caggggacca agctggagat caaa                                           324


<210>  73
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  74

Arg Ala Ser Gln Ser Ile Asn Gly Tyr Leu Asn 
1               5                   10      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  75

Ala Thr Ser Ser Leu Gln Ser 
1               5           


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  76

Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr 
1               5                   10  


<210>  77
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  77
gacatccaga tgacccagtc tccactctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggcgagtcg ggacattaga aactatttaa attggtatca acaaaaacca    120

gggaaagccc cgaagctcct gatctacgat gcatccagtt tgcaaacagg ggtcccatca    180

aggttcggtg gcagtggatc tgggacagac tttagtttca ccatcggcag cctgcagcct    240

gaagatattg caacatatta ctgtcaacag tttgatagtc tccctcacac ttttggccag    300

gggaccaaac tggagatcaa a                                              321


<210>  78
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Gly Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Asp Ser Leu Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  79

Gln Ala Ser Arg Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  80

Asp Ala Ser Ser Leu Gln Thr 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  81

Gln Gln Phe Asp Ser Leu Pro His Thr 
1               5                   


<210>  82
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  82
gacatccaga tgacccagtt tccagccacc ctgtctgtgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttatg aggaacttag cctggtacca gcagaaacct    120

ggccagcctc ccaggctcct catctatggt gcatccaaaa gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagcc ttcactctca ccatcagcaa cctagagcct    240

gaagattttg cagtttatta ctgtcaccaa cgtagcacct ggcctctggg gactttcggc    300

cctgggacca aactggaggc caaa                                           324


<210>  83
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  83

Asp Ile Gln Met Thr Gln Phe Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Met Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Thr Trp Pro Leu 
                85                  90                  95      


Gly Thr Phe Gly Pro Gly Thr Lys Leu Glu Ala Lys 
            100                 105             


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  84

Arg Ala Ser Gln Ser Val Met Arg Asn Leu Ala 
1               5                   10      


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  85

Gly Ala Ser Lys Arg Ala Thr 
1               5           


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  86

His Gln Arg Ser Thr Trp Pro Leu Gly Thr 
1               5                   10  


<210>  87
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  87
gacatccaga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgga ggtcactttc    300

ggccctggga ccaaagtgga tatcaaa                                        327


<210>  88
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Glu Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  89

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  90

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  91

Gln Gln Arg Ser Asn Trp Pro Pro Glu Val Thr 
1               5                   10      


<210>  92
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain

<400>  92
gacatccaga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc     60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct    120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttacttggc atctacccgg    180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc    240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact    300

tggacgttcg gccaagggac caaggtggaa atcaaa                              336


<210>  93
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  94

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  95

Leu Ala Ser Thr Arg Glu Ser 
1               5           


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  96

Gln Gln Tyr Tyr Ser Thr Trp Thr 
1               5               


<210>  97
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  97
gaagttgtgc tcacccagtc tccaaccgcc atggctgcat ctcccgggga gaagatcact     60

atcacctgca gtgccagctc aactttaagt tccaattact tgcattggta tcagcagaag    120

ccaggattct cccctaaact cttgatttat aggacatcca atctggcctc tggagtccca    180

ggtcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaattgg caccatggag    240

gctgaagatg ttgccactta ctactgccag cagggtagta gtataccgct cacgttcggt    300

gctgggacca agctggagct gaag                                           324


<210>  98
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  98

Glu Val Val Leu Thr Gln Ser Pro Thr Ala Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Thr Leu Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Ile Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  99

Ser Ala Ser Ser Thr Leu Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  100

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  101

Gln Gln Gly Ser Ser Ile Pro Leu Thr 
1               5                   


<210>  102
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  102
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc     60

atctcatgca gggccagcaa aagtgtcagt acatctgcct atagttatat gcactggtac    120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct    180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat    240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtat    300

acgttcggag gggggaccaa gctggaaatc                                     330


<210>  103
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  103

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  104

Arg Ala Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  105

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  106

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  107
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  107
gatatccaga tgacacagac tacatcctcc ctatctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca    120

gatggaacta ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaacaa    240

gaagattttg ccacttactt ttgccaacag ggtaaaacgc ttccgtggac gttcggtgga    300

ggcaccaagc tggaaatcaa a                                              321


<210>  108
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  108

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  109

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  110
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  110

Thr Ser Arg Leu His Ser 
1               5       


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  111

Gln Gln Gly Lys Thr Leu Pro Trp Thr 
1               5                   


<210>  112
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  112
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aattatttaa attggtatca gcagaaacca    120

gatggatctg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaacaa    240

gaagatattg ccacttactt ttgccaacag ggaaagacgc ttccgtggac gttcggtgga    300

ggcaccaagc tggaaatcaa a                                              321


<210>  113
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  113

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  114

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  115

Thr Ser Arg Leu His 
1               5   


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  116

Gln Gln Gly Lys Thr Leu Pro Trp Thr 
1               5                   


<210>  117
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  117
gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc     60

atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg    120

tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc    180

tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc    240

agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacttccg    300

tacacgttcg gaggggggac caagctggaa atcaaa                              336


<210>  118
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  118

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  119

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  120

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable light chain sequence

<400>  121

Ala Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  122
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody heavy chain signal sequence

<400>  122

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser 
            


<210>  123
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  123
cgaacaggcc cagctggcca ccatggacat gagggtcccc gctcagctcc tggggctcct     60

tctgctctgg ctcccaggtg ccagatgtga catccagatg acccag                   106


<210>  124
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  124
tcgcacggcg cgcctcaaca ctctcccctg ttgaagc                              37


<210>  125
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  125
cggccaccat gggttggagc ctcatcttgc tcttccttgt cgctgttgct acgcgtgtcc     60

tgtccgaagt tcaattgtta gag                                             83


<210>  126
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  126
gggatcggcc agctgggccc cttcgttgag gcgcttgaga cggtgac                   47


<210>  127
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody heavy chain signal peptide

<400>  127

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  128
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody light chain signal peptide

<400>  128

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  129
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody light chain signal peptide

<400>  129

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  130
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  130
ggggatatcc accatggrat gsagctgkgt matsctctt                            39


<210>  131
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  131
aggtctagaa yctccacaca caggrrccag tggatagac                            39


<210>  132
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  132
ggggatatcc accatggatt ttcaggtgca gattttcag                            39


<210>  133
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  133
gcgtctagaa ctggatggtg ggagatgga                                       29


<210>  134
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding antibody chimeric heavy chain

<400>  134
atggaatgga gctgtgtcat gctcttcatc ctgtcaggaa ctgcaggtgt ccactcccag     60

gttcagctgc agcagtctgg acctgagcta gtgaagcctg gggcttcagt gaagatgtcc    120

tgcaaggctt ctggaaacac attcactgac tatgttataa actgggtgaa gcagagaact    180

ggacagggcc ttgagtggat tggagagatt tatcctggaa atgaaaatac ttattacaat    240

gagaagttca agggcaaggc cacactgact gcagacaaat cctccaacac agcctacatg    300

cagctcagta gcctgacatc tgaggactct gcggtctatt tctgtgcaag agggatttat    360

tactacggta gtaggacgag gactatggac tactggggtc aaggaacctc agtcaccgtc    420

tcctcagcct ccaccaaggg cccatccgtc ttccccctgg cgccctgctc cagatctacc    480

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accggtgacg    540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag    600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg    660

aagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagagagtt    720

gagtccaaat atggtccccc atgcccaccg tgcccagcac ctgagttcct ggggggacca    780

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag    840

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac    900

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc    960

gcgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag   1020

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa   1080

gccaaagggc agccccgaga gccacaagtg tacaccctgc ccccatccca ggaggagatg   1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc   1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtcctc   1260

gattccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag   1320

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag   1380

aagagcctct ccctgtctct gggttga                                       1407


<210>  135
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chimeric heavy chain

<400>  135

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Asn Glu Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Tyr Tyr Tyr Gly Ser Arg Thr Arg Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Ala Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210>  136
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  136
cgccagtgtg cggccgctgg aattcgccct tg                                   32


<210>  137
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide PCR primer

<400>  137
ggaccaagct ggagctgaag cgtacggatg ctgcaccaac tgtatcc                   47


<210>  138
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody light chain

<400>  138
atggattttc aggtgcagat tttcagcttg ctgctaatca gtgtcacagt catagtgtct     60

aatggagaag ttgtgctcac ccagtctcca accgccatgg ctgcatctcc cggggagaag    120

atcactatca cctgcagtgc cagctcaact ttaagttcca attacttgca ttggtatcag    180

cagaagccag gattctcccc taaactcttg atttatagga catccaatct ggcctctgga    240

gtcccaggtc gcttcagtgg cagtgggtct gggacctctt actctctcac aattggcacc    300

atggaggctg aagatgttgc cacttactac tgccagcagg gtagtagtat accgctcacg    360

ttcggtgctg ggaccaagct ggagctgaag cgtacggtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag          714


<210>  139
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody light chain

<400>  139

Glu Val Val Leu Thr Gln Ser Pro Thr Ala Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Thr Leu Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Ile Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  140
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody heavy chain

<400>  140
atggactgga cctggagggt cttctgcttg ctggctgtag caccaggtgc ccactccgac     60

gtccaactgc aggagtctgg acctgacctg gtgaaacctt ctcagtcact ttcactcacc    120

tgcactgtca ctggctactc catcaccagt ggttatagct ggcactggat ccggcagttt    180

ccaggaaaca aactggaatg gatgggctac atacactaca gtggtggcac taactacaac    240

ccatctctca aaagtcgaat ctctatcact cgagacacat ccaagaacca gttcttcctc    300

cagttgaatt ctgtgactac tgaggacaca gccacatatt actgtgcaag atcggggtac    360

ggctacagga gtgcgtacta ttttgactac tggggccaag ggaccacggt caccgtctcc    420

tcagcttcca ccaagggccc atccgtcttc cccctggcgc cctgctccag atctacctcc    480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag    660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag    720

tccaaatatg gtcccccatg cccaccgtgc ccagcacctg agttcctggg gggaccatca    780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc    840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg    900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcgcg    960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac   1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc   1080

aaagggcagc cccgagagcc acaagtgtac accctgcccc catcccagga ggagatgacc   1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg   1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtcctcgat   1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag   1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag   1380

agcctctccc tgtctctggg ttga                                          1404


<210>  141
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody heavy chain

<400>  141

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Gly Tyr Arg Ser Ala Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Ala Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


<210>  142
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody light chain

<400>  142
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccactggt     60

gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc    120

atctcatgca gggccagcaa aagtgtcagt acatctgcct atagttatat gcactggtac    180

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct    240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat    300

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtat    360

acgttcggag gggggaccaa gctggaaatc aaacgtacgg tggctgcacc atctgtcttc    420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg    480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg    540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc    600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc    660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag       717


<210>  143
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody light chain

<400>  143

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  144
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody heavy chain

<400>  144
atggactgga cctggagggt cttctgcttg ctggctgtag caccaggtgc ccactccgac     60

gtccaactgc aggagtctgg acctgacctg gtgaaacctt ctcagtcact ttcactcacc    120

tgcactgtca ctggctactc catcaccagt ggttatagct ggcactggat ccggcagttt    180

ccaggaaaca aactggaatg gatgggctac atacactaca gtggtggcac taactacaac    240

ccatctctca aaagtcgaat ctctatcact cgagacacat ccaagaacca gttcttcctc    300

cagttgaatt ctgtgactac tgaggacaca gccacatatt actgtgcaag atcggggtac    360

ggctacagga gtgcgtacta ttttgactac tggggccaag ggaccacgtt gacagtctcc    420

tcagcttcca ccaagggccc atccgtcttc cccctggcgc cctgctccag atctacctcc    480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag    660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag    720

tccaaatatg gtcccccatg cccaccgtgc ccagcacctg agttcctggg gggaccatca    780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc    840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg    900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcgcg    960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac   1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc   1080

aaagggcagc cccgagagcc acaagtgtac accctgcccc catcccagga ggagatgacc   1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg   1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtcctcgat   1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag   1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag   1380

agcctctccc tgtctctggg ttga                                          1404


<210>  145
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody heavy chain

<400>  145

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Gly Tyr Arg Ser Ala Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Ala Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


<210>  146
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody heavy chain

<400>  146
atgggttgga tctgtatctt tctattcttg gtggcagctg cccaaagtgc ccaagcacag     60

atccagttgg tgcagtctgg acctgacctg aagaagcctg gagagacagt caagatctcc    120

tgcaaggctt ctgggtatac cttcacaaac catggaatga actgggtgaa gcaggctcca    180

ggaaaggatt taaagtggat gggctggata aacaccaaca ctggagagcc aacatatgct    240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg    300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgcaag tcccctctac    360

tataggaacg ggcgatactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca    420

gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccagatc tacctccgag    480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc    660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc    720

aaatatggtc ccccatgccc accgtgccca gcacctgagt tcctgggggg accatcagtc    780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg    840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat    900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcgcgtac    960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag   1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa   1080

gggcagcccc gagagccaca agtgtacacc ctgcccccat cccaggagga gatgaccaag   1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag   1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt cctcgattcc   1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg   1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc   1380

ctctccctgt ctctgggttg a                                             1401


<210>  147
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody heavy chain

<400>  147

Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Asp Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Pro Leu Tyr Tyr Arg Asn Gly Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Ala Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  148
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody light chain

<400>  148
atgaggtccc ctgctcagtt tcttggtctc ctgttgctct gttttcaagg tgccagatgt     60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc    120

atcagttgca gggcaagtca ggacattagt aattatttaa attggtatca gcagaaacca    180

gatggatctg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaacaa    300

gaagatattg ccacttactt ttgccaacag ggaaagacgc ttccgtggac gttcggtgga    360

ggcaccaagc tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                    705


<210>  149
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody light chain

<400>  149

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  150
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody heavy chain

<400>  150

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Asn Thr Ser Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ser Tyr Phe Cys Ala 
                85                  90                  95      


Ser Pro Leu Tyr Tyr Met Tyr Gly Arg Tyr Ile Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Ala Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  151
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding chimeric antibody light chain

<400>  151
atgaggtccc ctgctcagtt tcttggagac ctgttgctct gttttcaagg taccagatgt     60

gatatccaga tgacacagac tacatcctcc ctatctgcct ctctgggaga cagagtcacc    120

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca    180

gatggaacta ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaacaa    300

gaagattttg ccacttactt ttgccaacag ggtaaaacgc ttccgtggac gttcggtgga    360

ggcaccaagc tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                    705


<210>  152
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antibody light chain

<400>  152

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  153
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding antibody light chain constant domain

<400>  153
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct     60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag    120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac    180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag    240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag    300

agcttcaaca ggggagagtg ttga                                           324


<210>  154
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody light chain constant domain

<400>  154

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  155
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding antibody aglycosylated heavy chain constant domain

<400>  155
gcctcaacga aggggcccag cgtgttcccc ctggcgccct gctccaggag cacctccgag     60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc    240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc    300

aaatatggtc ccccatgccc accgtgccca gcacctgagt tcctgggggg accatcagtc    360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg    420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat    480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcgcgtac    540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag    600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa    660

gggcagcccc gagagccaca agtgtacacc ctgcccccat cccaggagga gatgaccaag    720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag    780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt cctcgattcc    840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg    900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc    960

ctctccctgt ctctgggttg a                                              981


<210>  156
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody aglycosylated heavy chain constant domain

<400>  156

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Ala Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  157
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin light chain signal peptide

<400>  157

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20         

